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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 623886Generated: October 29, 2026

1-Bromo-2-butanone → methyl 3-[4-[5-(5-ethyl-1H-imidazol-2-yl)-2-pyridyl]phenoxy]-2,2-dimethylpropanoate

https://huagongshe.com/reaction/623886

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-2-butanoneHCID 13156—
ReactantMethyl 3-(4-{5-[amino(imino)methyl]pyridin-2-yl}phenoxy)-2,2-dimethylpropanoate acetateHCID 67973181—
Productmethyl 3-[4-[5-(5-ethyl-1H-imidazol-2-yl)-2-pyridyl]phenoxy]-2,2-dimethylpropanoateHCID 67975432101.3%

Reaction Steps

By using methyl 3-(4-{5-[amino (imino)methyl]pyridin-2-yl) phenoxy)-2,2-dimethylpropanoate acetate (400 mg), and 1-bromobutan-2-one (234 mg), the procedure was carried out in the same manner as in Example 35(2) to obtain methyl 3-[4-[5-[5-ethyl-1H-imidazol-2-yl)-2-pyridyl]phenoxy]-2,2-dimethylpropanoate (397 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09302996B2
Source datasetuspto-grants-2016_04
ORD IDord-38bd14d0242f4131a629c0b120170c49
Source noteuspto-grants-2016_04