HCID 67973729, compound → HCID 86698174, compound

HRID 623897Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][C:23]=1B1OC(C)(C)C(C)(C)O1)[O:6][CH2:7][C:8]([CH3:20])([CH3:19])[C:9]([O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:10].Br[C:34]1[CH:39]=[CH:38][C:37]([C:40]2[N:41]([CH2:49][O:50][CH2:51][CH2:52][Si:53]([CH3:56])([CH3:55])[CH3:54])[CH:42]=[C:43]([C:45]([F:48])([F:47])[F:46])[N:44]=2)=[CH:36][N:35]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:21]=[CH:22][C:23]=1[C:34]1[CH:39]=[CH:38][C:37]([C:40]2[N:41]([CH2:49][O:50][CH2:51][CH2:52][Si:53]([CH3:56])([CH3:55])[CH3:54])[CH:42]=[C:43]([C:45]([F:46])([F:47])[F:48])[N:44]=2)=[CH:36][N:35]=1)[O:6][CH2:7][C:8]([CH3:19])([CH3:20])[C:9]([O:11][CH2:12][C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)=[O:10]

Participants

Reactant 2

HCID 67973729HCID 67973729, compound

HCID 86698175HCID 86698175, compound

Product 1

HCID 86698174HCID 86698174, compoundYield 83.3%

Procedure

By using benzyl 3-[3-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-phenoxy]-2,2-dimethylpropanoate (1.03 g) and 2-bromo-5-[4-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]pyridine (494 mg), the procedure was carried out in the same manner as in Reference example 1-3) to obtain benzyl 3-[3-methoxy-4-[5-[4-(trifluoromethyl)-1-(2-trimethylsilylethoxymethyl)imidazol-2-yl]-2-pyridyl]phenoxy]-2,2-dimethylpropanoate (639 mg).

Sources & evidence

ORD record: ord-94278eed74e94aa59b347034d2cbfe4d
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09302996B2

Reaction notes

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