反应详情

In trifluoroacetic acid (5.0 mL) and water (0.5 mL) was dissolved 1-{[(5-{3-chloro-4-[4-(trifluoromethyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl]phenyl}-4-methylpyridin-2-yl)oxy]methyl}cyclopropanecarboxylic acid (219 mg), and the solution was stirred at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure, a small amount of tetrahydrofuran was added to the residue, and the mixture was neutralized by 1N aqueous sodium hydroxide solution. Several drops of acetic acid was added to the mixture, the mixture was extracted with ethyl acetate, washed with a saturated brine, and the organic layer was separated and concentrated under reduced pressure. Isopropyl ether was added to the obtained residue, and the precipitated solid was collected by filtration and dried under reduced pressure to obtain 1-{[(5-{3-chloro-4-[5-(trifluoromethyl)-1H-imidazol-2-yl]phenyl}-4-methylpyridin-2-yl)oxy]methyl}cyclopropanecarboxylic acid (95 mg).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. additiona small amount of tetrahydrofuran was added to the residue
3. additionSeveral drops of acetic acid was added to the mixture
4. extractionthe mixture was extracted with ethyl acetate
5. washwashed with a saturated brine
6. customthe organic layer was separated
7. concentrationconcentrated under reduced pressure
8. additionIsopropyl ether was added to the obtained residue
9. filtrationthe precipitated solid was collected by filtration
10. customdried under reduced pressure