HCID 68778515, compound → HCID 67975297, compound

HRID 623935Notes

Reaction equation

[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12](B2OC(C)(C)C(C)(C)O2)=[CH:11][C:10]=1[CH3:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[C:26]1[CH:31]=[CH:30][C:29]([C:32]2[N:33]([CH2:41][O:42][CH2:43][CH2:44][Si:45]([CH3:48])([CH3:47])[CH3:46])[CH:34]=[C:35]([C:37]([F:40])([F:39])[F:38])[N:36]=2)=[CH:28][N:27]=1>>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:26]2[N:27]=[CH:28][C:29]([C:32]3[N:33]([CH2:41][O:42][CH2:43][CH2:44][Si:45]([CH3:48])([CH3:47])[CH3:46])[CH:34]=[C:35]([C:37]([F:39])([F:40])[F:38])[N:36]=3)=[CH:30][CH:31]=2)=[CH:11][C:10]=1[CH3:24])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 68778515HCID 68778515, compound

HCID 86698175HCID 86698175, compound

Product 1

HCID 67975297HCID 67975297, compoundYield 99.7%

Procedure

By using 2-(4-benzyloxy-3-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1.08 g) and 2-bromo-5-[4-(trifluoromethyl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-1H-imidazol-2-yl]pyridine (0.7 g), the procedure was carried out in the same manner as in Reference example 1-3) to obtain 2-[[2-[6-(4-benzyloxy-3-methylphenyl)-3-pyridyl]-4-(trifluoromethyl)imidazol-1-yl]methoxy]ethyltrimethylsilane (0.892 g).

Sources & evidence

ORD record: ord-f08b3a51270f4e2183b7f57ff7fc6ca2
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09302996B2

Reaction notes

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