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HRID 623963作成日：2026年10月25日
6-Bromo-4-hydroxy-3-phenoxyquinolin-2(1H)-one → 6-Bromo-3-(4-chlorophenoxy)-N,N-diethyl-4-(trifluoromethyl)quinolin-2-amine
https://huagongshe.com/reaction/623963
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 6-Bromo-4-hydroxy-3-phenoxyquinolin-2(1H)-one | HCID 86715444 | — |
| 反応物 | 6-bromo-3-(4-chlorophenoxy)-4-(trifluoromethyl)quinolin-2(1H)-one | HCID 86715448 | — |
| 生成物 | 6-Bromo-3-(4-chlorophenoxy)-N,N-diethyl-4-(trifluoromethyl)quinolin-2-amine | HCID 86715449 | — |
反応手順
The title compound was prepared using 6-bromo-2-chloro-3-(4-chlorophenoxy)-4-(trifluoromethyl)quinoline (Intermediate 7, step d) in place of 6-bromo-2,4-dichloro-3-phenoxyquinoline (Intermediate 5, step c) according to the procedure described in Intermediate 5, step d except the reaction mixture was heated at 60° C. under reflux condenser for 12 hours.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US09303015B2 |
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| 出典データセット | uspto-grants-2016_04 |
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| ORD ID | ord-c7bd763717f44885b5976c4f9561b6f5 |
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| 出典メモ | uspto-grants-2016_04 |
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