Phenoxyacetyl chloride → 6-Bromo-3-phenoxy-4-(trifluoromethyl)quinolin-2(1H)-one

HRID 623965Notes

Reaction equation

HRID 623965 reaction equation
O(CC(Cl)=O)C1C=CC=CC=1.[Br:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[NH:19][C:18](=[O:23])[C:17]([O:24][C:25]1[CH:30]=[CH:29][C:28](Cl)=[CH:27][CH:26]=1)=[C:16]2[C:32]([F:35])([F:34])[F:33]>>[Br:12][C:13]1[CH:14]=[C:15]2[C:20](=[CH:21][CH:22]=1)[NH:19][C:18](=[O:23])[C:17]([O:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[C:16]2[C:32]([F:34])([F:33])[F:35]

Participants

3

Reactant 2

HCID 69703Phenoxyacetyl chlorideHCID 867154486-bromo-3-(4-chlorophenoxy)-4-(trifluoromethyl)quinolin-2(1H)-one

Product 1

HCID 867154516-Bromo-3-phenoxy-4-(trifluoromethyl)quinolin-2(1H)-one

Procedure

The title compound was prepared using commercially available 2-phenoxyacetyl chloride in place of 2-(4-chlorophenoxy)acetyl chloride according to the procedure described in Intermediate 7, step c.

Sources & evidence

ORD record
ord-0c1cf17af9b74ea59a2ae4c834a0c114
Source dataset
uspto-grants-2016_04
Patent number
US09303015B2

Reaction notes

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