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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 623968Generated: October 29, 2026

Methyl 5-bromo-2-(2-(4-chlorophenoxy)acetamido)benzoate → 6-Bromo-3-(4-chlorophenoxy)-4-hydroxyquinolin-2(1H)-one

https://huagongshe.com/reaction/623968

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 5-bromo-2-(2-(4-chlorophenoxy)acetamido)benzoateHCID 7765743—
ReactantMethyl 5-bromo-2-(2-phenoxyacetamido)benzoateHCID 7765744—
Reactant6-Bromo-4-hydroxy-3-phenoxyquinolin-2(1H)-oneHCID 86715444—
Product6-Bromo-3-(4-chlorophenoxy)-4-hydroxyquinolin-2(1H)-oneHCID 86715454—

Reaction Steps

The title compound was prepared using methyl 5-bromo-2-(2-(4-chlorophenoxy)acetamido)benzoate (Intermediate 9, step a) in place of methyl 5-bromo-2-(2-phenoxyacetamido)benzoate (Intermediate 5, step a) according to the procedure described in Intermediate 5, step b.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09303015B2
Source datasetuspto-grants-2016_04
ORD IDord-c4cd5b8d6e32433ca54d43284558b408
Source noteuspto-grants-2016_04