HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → 6-Bromo-4-hydroxy-3-(isopropyl(phenyl)amino)quinolin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | N-Isopropylaniline | HCID 13032 | — |
| Reactant | (6-Bromo-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)(phenyl) iodoniumtrifluoromethane sulfonate | HCID 86715456 | — |
| Product | 6-Bromo-4-hydroxy-3-(isopropyl(phenyl)amino)quinolin-2(1H)-one | HCID 86715461 | — |
Reaction Steps
The title compound was prepared using N-isopropylaniline at 50° C. in place of aniline at room temperature according to the procedure of Intermediate 11, step c except the crude solid was purified by flash column chromatography (silica gel, 50% EtOAc-Heptane), affording the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303015B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-b82909726f8c4d47a492ec43f530b0e0 |
| Source note | uspto-grants-2016_04 |