反应详情

温度

0 °C

To a 100 mL RB flask fitted with magnetic stirrer was charged tert-butyl 5-carbamoyl-2-azatricyclo[3.3.1.13,7]decane-2-carboxylate, Intermediate-11 (0.1 g, 0.0357 mmol) in DCM (5 mL). The reaction mixture was cooled to 0° C. and trifluoroacetic acetic anhydride (0.21 g, 0.17 mmol) was added and stirred for 4 hours. After completion of the reaction (reaction was monitored by LCMS) reaction mixture was concentrated followed by trituration with mixture of hexane:ether (1:1) to give Intermediate-12 (0.09 g, yield=90%).

1. customTo a 100 mL RB flask fitted with magnetic stirrer
2. customAfter completion of the reaction (reaction was monitored by LCMS) reaction mixture
3. concentrationwas concentrated
4. additionfollowed by trituration with mixture of hexane:ether (1:1)
5. customto give Intermediate-12 (0.09 g, yield=90%)