Thionyl Chloride → HCID 6423259, compound

Participants

Reaction Steps

To a solution of 2-(2-methyl-1H-benzoimidazol-1-yl)ethanol (4.00 g, 22.70 mmol) in DCM (80 mL) at 0° C., thionylchloride (3.5 mL, 48.25 mmol) was added. The reaction mixture was allowed to warm to rt and stirred for 5 h at this temperature, then the reaction mixture was quenched with aq. sat. NaHCO3-solution (gas evolution) and extracted with DCM (3×). The org. layers was dried (MgSO4), filtered and the solvent was removed under reduced pressure to yield 1-(2-chloroethyl)-2-methyl-1H-benzoimidazole which was used without further prufication in the next step. LC-MS conditions B: tR=0.37 min, [M+H]+=195.09.

Provenance & Evidence