Cesium carbonate → HCID 86704206, compound

Participants

Reaction Conditions

Reaction Steps

To 1-(2-chloroethyl)-2-methyl-1H-benzoimidazole) (4.42 g, 22.71 mmol), in MeCN (50 mL), 4-nitro-1H-pyrazole (2.57 g, 22.71 mmol) and Cs2CO3 (8.14 g, 24.98 mmol) was added. After stirring at 80° C. for 18 h the reaction mixture was allowed to reach rt and filtered. The filter cake was washed with DCM and the filtrate was concentrated in vacuo, then the residue was dissolved in DCM and washed with H2O. The combined aq. layers were reextracted with DCM, the combined org. layers were dried (MgSO4), filtered and the solvent removed under reduced pressure to yield 2-methyl-1-(2-(4-nitro-1H-pyrazol-1-yl)-ethyl)-1H-benzoimidazole, which is used in the next step without further purification. LC-MS conditions B: tR=0.42 min, [M+H]+=272.07.

Provenance & Evidence