1-(3-fluorophenethyl)-4-nitro-1H-pyrazole → HCID 68283584, compound

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Reaction Steps

To a round bottom flask 1-(3-fluorophenethyl)-4-nitro-1H-pyrazole (785 mg, 3.34 mmol), Pd/C (79 mg) and MeOH (10.0 mL, degassed) was added. The flask was evacuated and backfilled with H2 and the reaction mixture was stirred under H2-atmosphere at rt for 18 h. The reaction mixture was filtered over celite, washed with MeOH and the solvent was removed under reduced pressure to yield 1-[2-(3-Fluoro-phenyl)-ethyl]-1H-pyrazol-4-ylamine as a red oil which was used without further purification. LC-MS conditions B: tR=0.41 min; [M+MeCN+H]+=247.32.

Provenance & Evidence