5-methoxy-1-(3-(4-nitro-1H-pyrazol-1-yl)propyl)indoline → 1-[3-(5-Methoxy-2,3-dihydro-indol-1-yl)-propyl]-1H-pyrazol-4-ylamine

Participants

Reaction Steps

To a solution of 5-methoxy-1-(3-(4-nitro-1H-pyrazol-1-yl)propyl)indoline (1.18 mmol), in MeOH (6.0 mL, degassed), PtO2 (12 mg, 0.05 mmol) was added and the reaction mixture was stirred at rt under a H2-atmosphere for 18 h. The mixture was diluted with MeOH, filtered over celite and the filter cake was rinsed with MeOH. The filtrate was concentrated to obtain the title compound as a brown oil, which was used in the next step without further purification. LC-MS conditions B: tR=0.32 min, [M+H]+=273.1.

Provenance & Evidence