6-Methoxy-1H-indole → 1-[3-(6-Methoxy-2,3-dihydro-indol-1-yl)-propyl]-1H-pyrazol-4-ylamine

HRID 624041Notes

Reaction equation

HRID 624041 reaction equation
CO[C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][CH2:13][CH2:14][N:15]1[CH:19]=[C:18]([NH2:20])[CH:17]=[N:16]1)[CH2:7][CH2:6]2.[CH3:21][O:22]C1C=C2C(C=CN2)=CC=1>>[CH3:21][O:22][C:11]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][N:8]2[CH2:12][CH2:13][CH2:14][N:15]2[CH:19]=[C:18]([NH2:20])[CH:17]=[N:16]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 766596-Methoxy-1H-indoleHCID 682827831-[3-(5-Methoxy-2,3-dihydro-indol-1-yl)-propyl]-1H-pyrazol-4-ylamine

Product 1

HCID 682833761-[3-(6-Methoxy-2,3-dihydro-indol-1-yl)-propyl]-1H-pyrazol-4-ylamine

Procedure

The title compound was synthesized according to above mentioned procedure for 1-[3-(5-methoxy-2,3-dihydro-indol-1-yl)-propyl]-1H-pyrazol-4-ylamine, starting form 6-methoxyindole. LC-MS conditions B: tR=0.46 min, [M+H]+=273.23.

Sources & evidence

ORD record
ord-3e67116d393647bfa5e49aa9829da889
Source dataset
uspto-grants-2016_04
Patent number
US09303023B2

Reaction notes

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