Ethanol → ethyl 2-(5-methoxy-1H-indol-3-yl)-2-oxoacetate

Participants

Reaction Steps

To a solution 2-(5-methoxy-1H-indol-3-yl)-2-oxoacetyl chloride (14.78 g, 62.20 mmol) in ethanol (144 mL), Et3N (10.40 mL, 74.63 mmol) was added at 0° C. and the resulting yellow suspension was stirred at rt for 1 h. The percipitate was filtered off, washed with cold ethanol and diethylether to yield ethyl 2-(5-methoxy-1H-indol-3-yl)-2-oxoacetate as an orange oil. LC-MS conditions B: tR=0.63 min, [M+H]+=248.13.

Provenance & Evidence