HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-2-((tert-Butoxycarbonyl)amino)propyl 4-methylbenzenesulfonate → (R)-N-(1-(2-Aminopropyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-2-((tert-Butoxycarbonyl)amino)propyl 4-methylbenzenesulfonate | HCID 72710279 | — |
| Reactant | N-(1-(2-Aminoethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide | HCID 86704224 | — |
| Product | (R)-N-(1-(2-Aminopropyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide | HCID 86704227 | — |
Reaction Steps
The title compound was synthesized according to procedure described for N-(1-(2-aminoethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide starting with (R)-2-((tert-butoxycarbonyl)amino)propyl 4-methylbenzenesulfonate. Synthesis of (R)-2-((tert-butoxycarbonyl)amino)propyl 4-methylbenzenesulfonate was performed according to Bioorg. Med. Chem. 16 (2008) 1966-1982. LC-MS conditions B: tR=0.55 min, [M+H]+=326.11.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303023B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-95639e7618f5435fa1dd0194289a404f |
| Source note | uspto-grants-2016_04 |