tert-butyl N-(3-bromopropyl)carbamate → N-(1-(3-Aminopropyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide

HRID 624078Notes

Reaction equation

HRID 624078 reaction equation
NCC[N:4]1[CH:8]=[C:7]([NH:9][C:10]([C:12]2[N:13]=[CH:14][O:15][C:16]=2[C:17]2[CH:18]=[C:19]([CH3:23])[CH:20]=[CH:21][CH:22]=2)=[O:11])[CH:6]=[N:5]1.C([NH:31][CH2:32][CH2:33][CH2:34]Br)(OC(C)(C)C)=O>>[NH2:31][CH2:32][CH2:33][CH2:34][N:4]1[CH:8]=[C:7]([NH:9][C:10]([C:12]2[N:13]=[CH:14][O:15][C:16]=2[C:17]2[CH:18]=[C:19]([CH3:23])[CH:20]=[CH:21][CH:22]=2)=[O:11])[CH:6]=[N:5]1

Participants

3

Reactant 2

HCID 4460490tert-butyl N-(3-bromopropyl)carbamateHCID 86704224N-(1-(2-Aminoethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide

Product 1

HCID 86704229N-(1-(3-Aminopropyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide

Procedure

The title compound was synthesized according to above mentioned procedure for N-(1-(2-aminoethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide, using 3-(Boc-amino)propyl bromide. LC-MS conditions B: tR=0.56 min, [M+H]+=326.19.

Sources & evidence

ORD record
ord-7271011da4784a56b393c53247b0a465
Source dataset
uspto-grants-2016_04
Patent number
US09303023B2

Reaction notes

Loading…