Methyl iodide → HCID 178503552, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-mercapto-5-methylpyrimidine-4,6-diol (2.08 g, 13.14 mmol) in 2 N aq. NaOH-solution (19.7 mL, 39.41 mmol) was cooled to 0° C., then MeI (2.07 mL, 32.84 mmol) was added dropwise and the resulting mixture was stirred at 0° C. for 1 h 40 and at rt for 2 h. The reaction mixture was concentrated to yield 5-methyl-2-(methylthio)pyrimidine-4,6-diol as a white solid which was used in the next step without further purification. LC-MS conditions

Provenance & Evidence