反应详情

To a solution of N-(1-(2-oxoethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide (157 mg, 0.45 mmol) in MeCN (1 mL) and DCM (0.8 mL) was added 1-methyl-1H-benzo[d]imidazol-2-amine (66 mg, 0.45 mmol) followed by STAB (190 mg, 0.90 mmol) and 1 drop of AcOH. After stirring at rt for 18 h, the reaction mixture was filtered and directly purified by prep. HPLC. LC-MS conditions D: tR=0.77 min, [M+H]+=442.3.

1. filtrationthe reaction mixture was filtered
2. customdirectly purified by prep