反应详情

温度

135 °C

In a 20 mL sealed tube under nitrogen, a mixture of tert-butyl piperazine-1-carboxylate (0.943 g, 5.06 mmol), 2-chloro-5-nitro-1H-benzo[d]imidazole (0.5 g, 2.53 mmol) and ethanol (9.5 mL) was heated at 135° C. for 2 hours. The reaction was concentrated and the residue was purified by reverse-phase chromatography to provide the title compound.

1. customIn a 20 mL sealed tube under nitrogen
2. concentrationThe reaction was concentrated
3. customthe residue was purified by reverse-phase chromatography