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Sodium bis(trimethylsilyl)amide → tert-butyl 4-(6-bromo-2-oxoquinolin-1(2H)-yl)butylcarbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| 反応物 | tert-butyl N-(4-bromobutyl)carbamate | HCID 10868765 | — |
| 反応物 | 6-Bromoquinolin-2(1H)-one | HCID 12378943 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | tert-butyl 4-(6-bromo-2-oxoquinolin-1(2H)-yl)butylcarbamate | HCID 68748860 | — |
反応手順
To a solution of 6-bromoquinolin-2(1H)-one (430 mg, 1.91 mmol) in tetrahydrofuran (8 ml) was added sodium bis(trimethylsilyl)amide (2.1 ml, 2.08 mmol). After 15 minutes, 4-(boc-amino)butyl bromide (403 mg, 1.6 mmol) was added. The solution was stirred for 15 hours, concentrated and purified by flash chromatography to provide the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09302989B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-e9c68693dd3244a891f81831e016611e |
| 出典メモ | uspto-grants-2016_04 |