化工社化工社 化学情報印刷レポート · 研究参考用
4-amino-N-propylbenzamide → 5-(hydroxymethyl)-N-(3-phenylpropyl)-1,3-dihydro-2H-isoindole-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-amino-N-propylbenzamide | HCID 428344 | — |
| 反応物 | methyl 2,3-dihydro-1H-isoindole-5-carboxylate hydrochloride | HCID 19828495 | — |
| 反応物 | (2,3-dihydro-1H-isoindol-5-yl)methanol hydrochloride | HCID 68754933 | — |
| 生成物 | 5-(hydroxymethyl)-N-(3-phenylpropyl)-1,3-dihydro-2H-isoindole-2-carboxamide | HCID 68749386 | — |
反応手順
The title compound was prepared as described in Example 272B, substituting 3-phenylpropan-1-amine for 4-amino-N-propylbenzamide and isoindolin-5-ylmethanol hydrochloride for methyl isoindoline-5-carboxylate hydrochloride. 1H NMR (300 MHz, DMSO-d6) δ ppm 7.30-7.14 (m, 8H), 6.30 (t, J=5.5 Hz, 1H), 5.16 (t, J=5.5 Hz, 1H), 4.55 (bs, 4H), 4.49 (d, J=4.9 Hz, 2H), 3.16-3.05 (m, 2H), 2.64-2.56 (m, 2H), 1.76 (p, J=7.4 Hz, 2H); MS (ESI(+)) m/e 311 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09302989B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-cec28866b4004f028d726af76c581c69 |
| 出典メモ | uspto-grants-2016_04 |