Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 624239Generated: October 25, 2026

2-Bromo-4'-nitroacetophenone → 5-(2-(2-Chlorobenzyl)thiazol-4-yl)thiophen-2-amine

https://huagongshe.com/reaction/624239

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-4'-nitroacetophenoneHCID 66840—
Reactant2-PhenylethanethioamideHCID 731368—
Reactant2-(2-Chlorophenyl)ethanethioamideHCID 2806785—
Product5-(2-(2-Chlorobenzyl)thiazol-4-yl)thiophen-2-amineHCID 68750560—

Reaction Steps

The title compound was prepared as described in Example 806A, substituting 2-bromo-1-(5-nitrothiophen-2-yl)ethanone for 2-bromo-1-(4-nitrophenyl)ethanone and 2-(2-chlorophenyl)ethanethioamide for 2-phenylethanethioamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09302989B2
Source datasetuspto-grants-2016_04
ORD IDord-86da2cf31f0d447f987e1ce787aea6f5
Source noteuspto-grants-2016_04