Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | p-Fluoronitrobenzene | HCID 9590 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | tert-butyl N-(azetidin-3-ylmethyl)carbamate | HCID 15346872 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86665088 | HCID 86665088 | — |
Reaction Steps
A solution of 1-fluoro-4-nitrobenzene (0.61 g, 4.32 mmol) and tert-butyl azetidin-3-ylmethylcarbamate (0.886 g, 4.76 mmol) in dimethylformamide (8.65 ml) was treated with potassium carbonate (0.896 g, 6.48 mmol) and the suspension was heated at 55° C. (12 pm) for 3 hours and at ambient temperature for 16 hours. The reaction was poured into water and the suspension was filtered. The solid was washed with water and dried to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09302989B2 |
|---|
| Source dataset | uspto-grants-2016_04 |
|---|
| ORD ID | ord-bad60dc2f85945eb975920c2e1aafef7 |
|---|
| Source note | uspto-grants-2016_04 |
|---|
