3-Phenylpropylamine → HCID 57510828, compound

HRID 624250Notes

Reaction equation

HRID 624250 reaction equation
C1(CCCN)C=CC=CC=1.[CH2:11]1[C:19]2[CH:18]=[CH:17][N:16]=[CH:15][C:14]=2[CH2:13][N:12]1[C:20]([NH:22][C:23]1[CH:28]=[CH:27][C:26]([N:29]2[CH2:32][CH:31]([C:33](O)=[O:34])[CH2:30]2)=[CH:25][CH:24]=1)=[O:21].[CH2:36]1[C:44]2[C:39](=[CH:40]C=CC=2)[CH2:38][N:37]1C(NC1C=CC(C(O)=O)=CC=1)=O>>[CH3:38][CH:39]([CH3:40])[CH2:44][CH2:36][NH:37][C:33]([CH:31]1[CH2:30][N:29]([C:26]2[CH:25]=[CH:24][C:23]([NH:22][C:20]([N:12]3[CH2:11][C:19]4[CH:18]=[CH:17][N:16]=[CH:15][C:14]=4[CH2:13]3)=[O:21])=[CH:28][CH:27]=2)[CH2:32]1)=[O:34]

Participants

4

Reactant 3

HCID 162593-PhenylpropylamineHCID 62230337HCID 62230337, compoundHCID 68751180HCID 68751180, compound

Product 1

HCID 57510828HCID 57510828, compound

Procedure

The title compound was prepared as described in Example 1C, substituting 3-methylbutan-1-amine for 3-phenylpropan-1-amine and 1-(4-(2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-2-carboxamido)phenyl)azetidine-3-carboxylic acid for 4-(isoindoline-2-carboxamido)benzoic acid. 1H NMR (300 MHz, DMSO-d6) δ ppm 8.59 (s, 1H), 8.49 (d, J=5.0 Hz, 1H), 8.13 (s, 1H), 7.90 (t, J=5.5 Hz, 1H), 7.42 (d, J=4.8 Hz, 1H), 7.34-7.27 (m, 2H), 6.41-6.34 (m, 2H), 4.79-4.73 (m, 4H), 3.94-3.85 (m, 2H), 3.76-3.69 (m, 2H), 3.47-3.36 (m, 1H), 3.13-3.04 (m, 2H), 1.65-1.48 (m, 1H), 1.35-1.24 (m, 2H), 0.87 (d, J=6.6 Hz, 6H); MS (ESI(+)) m/e 408 (M+H)+.

Sources & evidence

ORD record
ord-4f21250a0abd45078a177f43290934ff
Source dataset
uspto-grants-2016_04
Patent number
US09302989B2

Reaction notes

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