Acetyl chloride → HCID 68751010, compound

HRID 624258Notes

Reaction equation

HRID 624258 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[F:5][C:6]1[CH:25]=[CH:24][C:9]([CH2:10][NH:11][CH2:12][CH2:13][CH2:14][CH2:15][NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[CH:8][CH:7]=1.N[C:27]1[CH:28]=C2C(=C[CH:35]=1)CN(C(NC1C=CC(C(=O)NCCC)=CC=1)=O)C2>>[F:5][C:6]1[CH:7]=[CH:8][C:9]([CH2:10][N:11]([CH2:12][CH2:13][CH2:14][CH2:15][NH:16][C:17](=[O:23])[O:18][C:19]([CH3:21])([CH3:20])[CH3:22])[C:1](=[O:3])[CH2:2][CH:27]([CH3:28])[CH3:35])=[CH:24][CH:25]=1

Participants

4

Reactant 3

HCID 6367Acetyl chlorideHCID 10957433HCID 10957433, compoundHCID 57509898HCID 57509898, compound

Product 1

HCID 68751010HCID 68751010, compound

Procedure

The title compound was prepared as described in Example 278, substituting 3-methylbutanoyl chloride for acetyl chloride and tert-butyl 4-(4-fluorobenzylamino)butylcarbamate for 5-amino-N-(4-(propylcarbamoyl)phenyl)isoindoline-2-carboxamide.

Sources & evidence

ORD record
ord-2d805aa704be4037868103ef9c213b8a
Source dataset
uspto-grants-2016_04
Patent number
US09302989B2

Reaction notes

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