HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 67226237, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-(phenylmethoxy)-1H-indole | HCID 88465 | — |
| Reactant | Triisopropylsilyl chloride | HCID 139400 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67226237 | HCID 67226237 | — |
Reaction Steps
4-Benzyloxyindole (1 g) was treated with 60% oily NaH (135 mg) and triisopropylsilyl chloride (1 g) in THF, purified by flash chromatography (9812 ethyl acetate, hexanes), then debenzylated in ethanol (35 mL) using Pearlman's catalyst (0.19 g) and a hydrogen balloon.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303025B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-5d1b7829c65f4848976e219b18b8e82f |
| Source note | uspto-grants-2016_04 |