Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydro-4H-pyran-4-one → tert-butyl N-[1-(oxan-4-yl)piperidin-4-yl]carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydro-4H-pyran-4-one | HCID 121599 | — |
| 반응물 | 4-(N-Boc-amino)piperidine | HCID 723833 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | tert-butyl N-[1-(oxan-4-yl)piperidin-4-yl]carbamate | HCID 45792109 | — |
반응 단계
A mixture of tert-butyl piperidin-4-ylcarbamate (45 g) and dihydro-2H-pyran-4(3H)-one (24.74 g) in dichloromethane (1000 mL) was treated with sodium triacetoxyborohydride (61.9 g), stirred at room temperature for 16 hours, washed with 1M sodium hydroxide and dried with anhydrous sodium sulfate, filtered and concentrated. The concentrate was flash column chromatographed on silica gel with 10-20% methanol/dichloromethane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09303025B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-8ea3ef9cdeea49e6bb5fd928145d6f2e |
| 출처 메모 | uspto-grants-2016_04 |