HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-Fluoro-2-[(trifluoromethyl)sulfanyl]benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Trifluoroiodomethane | HCID 16843 | — |
| Reactant | 2-Fluorothiophenol | HCID 520216 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-Fluoro-2-[(trifluoromethyl)sulfanyl]benzene | HCID 47002880 | — |
Reaction Steps
Methyl viologen hydrochloride (1.17 g) in N,N-dimethylformamide (80 mL) at 25° C. was saturated with trifluoromethyl iodide, treated with 2-fluorobenzenethiol (9.7 mL) and triethylamine (20 mL), stirred for 24 hours, diluted with water (240 mL) and extracted with diethyl ether. The extract was washed with 1M aqueous NaOH, saturated ammonium chloride and brine and concentrated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303025B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-ec467a4372804a8b94ec7fe1ca4179e8 |
| Source note | uspto-grants-2016_04 |