反应详情

To a solution of 1-methyl-6,7-dihydro-1H-indazole-4-carboxylate (7.5 g, 38.7 mmol) and NiCl2 (4.9 g, 38.7 mmol) in MeOH (250 mL) was added NaBH4 (14 g, 387 mmol) in portions at 0° C. The resulting mixture was stirred at room temperature for further 1 hour. The solvent was removed and the residue was purified by column chromatography on silica gel (PE/THF=5/1 v/v %) to afford methyl 1-methyl-4,5,6,7-tetrahydro-1H-indazole-4-carboxylate (7 g, 94%).

1. customThe solvent was removed
2. customthe residue was purified by column chromatography on silica gel (PE/THF=5/1 v/v %)