HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 624426Generated: October 26, 2026
Ammonium Chloride → 4-Fluoro-2-[1-(4-methoxy-benzyl)-1h-benzotriazol-4-yloxy]-benzoic acid methyl ester
https://huagongshe.com/reaction/624426
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Methyl 2,4-Difluorobenzoate | HCID 2782897 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | 1-(4-methoxybenzyl)-1H-1,2,3-benzotriazol-4-ol | HCID 136343914 | — |
| Solvent | Diglyme | HCID 8150 | — |
| Product | 4-Fluoro-2-[1-(4-methoxy-benzyl)-1h-benzotriazol-4-yloxy]-benzoic acid methyl ester | HCID 67226997 | — |
Reaction Steps
To a solution of EXAMPLE 342C (990 mg) and methyl 2,4-difluorobenzoate (734 mg) in diglyme (40 mL) was added potassium tert-butoxide (1M in tetrahydrofuran, 4.07 mL). The solution was heated to 100° C. for 16 hours, cooled, added to saturated ammonium chloride, and extracted with 70% ethyl acetate in hexanes. The extract was washed with brine, dried over anhydrous sodium sulfate, filtered, concentrated and purified by flash column chromatography on silica gel using 30% ethyl acetate in hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09303025B2 |
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| Source dataset | uspto-grants-2016_04 |
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| ORD ID | ord-c0443b4d6baa4f44b69fe00a7a147c34 |
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| Source note | uspto-grants-2016_04 |
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