HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 624427Generated: October 31, 2026
Piperazine → 2-[1-(4-Methoxy-benzyl)-1h-benzotriazol-4-yloxy]-4-piperazin-1-yl-benzoic acid methyl ester
https://huagongshe.com/reaction/624427
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 4-Fluoro-2-[1-(4-methoxy-benzyl)-1h-benzotriazol-4-yloxy]-benzoic acid methyl ester | HCID 67226997 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-[1-(4-Methoxy-benzyl)-1h-benzotriazol-4-yloxy]-4-piperazin-1-yl-benzoic acid methyl ester | HCID 67227925 | — |
Reaction Steps
To a solution of EXAMPLE 342D (650 mg) in dimethylsulfoxide (12 mL) was added piperazine (618 mg). The solution was heated at 100° C. for one hour, cooled, added to dichloromethane, extracted with water three times, dried over anhydrous sodium sulfate, filtered, and the solvent was removed under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09303025B2 |
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| Source dataset | uspto-grants-2016_04 |
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| ORD ID | ord-9c7a7469b3f14831bb5b24fa3e3992c5 |
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| Source note | uspto-grants-2016_04 |
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