(Oxan-4-yl)methanol → 5-bromo-3-fluoro-2-((4-fluorotetrahydro-2H-pyran-4-yl)methoxy)pyridine

HRID 624462Notes

Reaction equation

HRID 624462 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][OH:8])[CH2:3][CH2:2]1.[Br:9][C:10]1[CH:11]=[C:12]([F:17])[C:13](F)=[N:14][CH:15]=1.[F:18]C1C=CC(S(N)(=O)=O)=CC=1[N+]([O-])=O>>[Br:9][C:10]1[CH:11]=[C:12]([F:17])[C:13]([O:8][CH2:7][C:4]2([F:18])[CH2:5][CH2:6][O:1][CH2:2][CH2:3]2)=[N:14][CH:15]=1

Participants

4

Reactant 3

HCID 2773573(Oxan-4-yl)methanolHCID 145496545-Bromo-2,3-difluoropyridineHCID 167824874-Fluoro-3-nitrobenzenesulfonamide

Product 1

HCID 671267205-bromo-3-fluoro-2-((4-fluorotetrahydro-2H-pyran-4-yl)methoxy)pyridine

Procedure

This example was prepared by substituting EXAMPLE 296C for (tetrahydro-2H-pyran-4-yl)methanol and 5-bromo-2,3-difluoropyridine for 4-fluoro-3-nitrobenzenesulfonamide in EXAMPLE 264A.

Sources & evidence

ORD record
ord-1c0293112df84d2981ec977dbfd343ad
Source dataset
uspto-grants-2016_04
Patent number
US09303025B2

Reaction notes

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