HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 1-tosyl-6,7-dihydro-1H-indazol-4(5H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | P-Toluenesulfonylhydrazide | HCID 15303 | — |
| Reactant | 2-[(Dimethylamino)methylidene]cyclohexane-1,3-dione | HCID 359353 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-tosyl-6,7-dihydro-1H-indazol-4(5H)-one | HCID 67458588 | 51.3% |
Reaction Steps
A solution of 2-((dimethylamino)methylene)cyclohexane-1,3-dione (55 g, 0.329 mol), 2-tosylhydrazine (61.3 g, 0.329 mol) and AcOH (33 mL) in EtOH (540 mL) was heated for 4 h at 70° C. Removed the solvent under reduced pressure and the residue was recrystallized using PE/EA=5/1 to give 1-tosyl-6,7-dihydro-1H-indazol-4(5H)-one (49 g, yield 51.3%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09446130B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-ecfba064d9a14925a662eb32c5e86b69 |
| Source note | uspto-grants-2016_09 |