HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → Methyl 4-morpholinocyclohex-3-enecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 1-Methyl-4-oxocyclohexane-1-carboxylic acid | HCID 22609943 | — |
| Catalyst | p-Toluenesulfonic acid | HCID 6101 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Methyl 4-morpholinocyclohex-3-enecarboxylic acid | HCID 71222953 | 103.3% |
Reaction Steps
The solution of methyl 4-oxocyclohexanecarboxylic acid (172.0 g, 1.01 mol), morpholine (97.0 g, 1.11 mol) and p-toluenesulfonic acid (200 mg) in toluene (500 mL) was stirred 18 h at reflux. The reaction mixture was concentrated in vacuum to give 235 g methyl 4-morpholinocyclohex-3-enecarboxylic acid. The compound was used in the next reaction without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09446130B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-742f57711c2543ef960c53012a8ae041 |
| Source note | uspto-grants-2016_09 |