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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 624522Generated: October 26, 2026

3-Fluoro-4-(methylcarbamoyl)benzeneboronic acid → Tert-butyl 3-(3-(3-fluoro-4-(methylcarbamoyl)phenyl)pyrazin-2-YL)azetidine-1-carboxylate

https://huagongshe.com/reaction/624522

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Fluoro-4-(methylcarbamoyl)benzeneboronic acidHCID 44717467—
ReactantTert-butyl 3-(3-chloropyrazin-2-yl)azetidine-1-carboxylateHCID 59351411—
ProductTert-butyl 3-(3-(3-fluoro-4-(methylcarbamoyl)phenyl)pyrazin-2-YL)azetidine-1-carboxylateHCID 86705405—

Reaction Steps

The compound was prepared analogously to Example 1 by using (3-fluoro-4-(methylcarbamoyl)phenyl)boronic acid (purchased from Combi Blocks) and tert-butyl 3-(3-chloropyrazin-2-yl)azetidine-1-carboxylate. m/z=287 (M+1-100).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09303028B2
Source datasetuspto-grants-2016_04
ORD IDord-5705c29220b947b59cf02dbe2d37f800
Source noteuspto-grants-2016_04