5-Chloro-2-furaldehyde → HCID 90218860, compound

Participants

Reaction Steps

The title compound was prepared from 5-(3-chlorophenyl)-6-(3-(dimethylamino)-2-hydroxypropyl)-1,3-dimethyl-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione and 5-chlorofuran-2-carbaldehyde analogously to Example 12, step 2. The first eluted diastereomer (by Agilent Prep. System (10-35%, low pH) was isolated and separated by SFC under the following conditions to yield the title compounds as single enantiomers.

Provenance & Evidence