反应详情

温度

100 °C

5-Benzoyl-6-(bromomethyl)-1,3-dimethyl-1H-pyrimidine-2,4-dione (step 3) (1 g, 2.97 mmol) in EtOH (12 mL) was treated with TEA (0.41 mL, 2.97 mmol) and tert-butyl 2-aminoethylcarbamate (commercial) (0.465 mL, 2.97 mmol). The mixture was heated to 100° C. for 1 h using microwave irradiation. After this time, a white precipitate had formed. The solid was collected via reduced pressure filtration and was washed with diethyl ether. The title compound was obtained as white needles.

1. custommicrowave irradiation
2. customAfter this time, a white precipitate had formed
3. filtrationThe solid was collected via reduced pressure filtration
4. washwas washed with diethyl ether