4-Bromo-2-methyl-1,3-thiazole → 1,3-Dimethyl-5-(2-methylthiazol-4-yl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

HRID 624612Notes

Reaction equation

HRID 624612 reaction equation
[CH3:1][N:2]1[C:7]2=[CH:8][NH:9][C:10]([C:11]3[CH:12]=C(C=CC=3)C#N)=[C:6]2[C:5](=[O:19])[N:4]([CH3:20])[C:3]1=[O:21].BrC1[N:24]=[C:25]([CH3:28])[S:26]C=1>>[CH3:1][N:2]1[C:7]2=[CH:8][NH:9][C:10]([C:11]3[N:24]=[C:25]([CH3:28])[S:26][CH:12]=3)=[C:6]2[C:5](=[O:19])[N:4]([CH3:20])[C:3]1=[O:21]

Participants

3

Reactant 2

HCID 27631864-Bromo-2-methyl-1,3-thiazoleHCID 867229283-(1,3-Dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile

Product 1

HCID 867229311,3-Dimethyl-5-(2-methylthiazol-4-yl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Procedure

The title compound was prepared by an analogous method to 3-(1,3-dimethyl-2,4-dioxo-2,3,4,6-tetrahydro-1H-pyrrolo[3,4-d]pyrimidin-5-yl)benzonitrile (Intermediate Ga) by replacing 3-bromobenzonitrile (step 3) with 4-bromo-2-methylthiazole.

Sources & evidence

ORD record
ord-22ee6aed76744e52b7861f8fe5fb9b37
Source dataset
uspto-grants-2016_04
Patent number
US09303035B2

Reaction notes

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