HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-fluorobenzonitrile → Methyl 4-bromo-2-fluorobenzimidate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-fluorobenzonitrile | HCID 736029 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | HCID 178508525 | HCID 178508525 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 4-bromo-2-fluorobenzimidate | HCID 71748447 | — |
Reaction Steps
Scheme 13 shows an alternative synthesis of 8-bromo-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-imine 33 from 4-bromo-2-fluorobenzonitrile 11. Reaction of 11 with sodium methoxide in methanol gives methyl 4-bromo-2-fluorobenzimidate 35. Alkylation of 35 with 2-aminoethanol gives 4-bromo-2-fluoro-N-(2-hydroxyethyl)benzimidamide 36, followed by cyclization to 33.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303043B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-81813203f6ec467fa38bf640a06cc216 |
| Source note | uspto-grants-2016_04 |