Ethanol → Ethyl 2-methyl-2-(1H-pyrazol-1-yl)propanoate

HRID 624632Notes

Reaction equation

[CH3:1][C:2]([N:7]1[CH:11]=[CH:10][CH:9]=[N:8]1)([CH3:6])[C:3]([OH:5])=[O:4].S(=O)(=O)(O)O.[CH2:17](O)[CH3:18]>>[CH3:6][C:2]([N:7]1[CH:11]=[CH:10][CH:9]=[N:8]1)([CH3:1])[C:3]([O:5][CH2:17][CH3:18])=[O:4]

Participants

Reactant 3

HCID 702Ethanol

HCID 1118Sulfuric Acid

HCID 2763345alpha,alpha-Dimethyl-1H-pyrazole-1-acetic acid

Product 1

HCID 90403665Ethyl 2-methyl-2-(1H-pyrazol-1-yl)propanoate

Procedure

2-Methyl-2-(1H-pyrazol-1-yl)propanoic acid 16 was treated with sulfuric acid in ethanol to give 17.

Sources & evidence

ORD record: ord-84d6210842dc4b6b9454c39333957479
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09303043B2

Reaction notes

Loading…