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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 624638Generated: October 31, 2026

1-Methylimidazole → Ethyl 2-(4-bromo-2-fluorophenyl)-1-(2-hydroxyethyl)-1H-imidazole-4-carboxylate

https://huagongshe.com/reaction/624638

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-MethylimidazoleHCID 1390—
ReactantEthylene carbonateHCID 7303—
ReactantHCID 178469883HCID 178469883—
ProductEthyl 2-(4-bromo-2-fluorophenyl)-1-(2-hydroxyethyl)-1H-imidazole-4-carboxylateHCID 85472880—

Reaction Steps

Ethyl 2-(4-bromo-2-fluorophenyl)-1H-imidazole-4-carboxylate 26 and 1,3-dioxolan-2-one and N-methylimidazole were reacted to give 27.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09303043B2
Source datasetuspto-grants-2016_04
ORD IDord-ae879755a56f477c910695c3422ecf07
Source noteuspto-grants-2016_04