反应详情

Ethyl 2-(4-bromo-2-fluorophenyl)-1-(2-hydroxyethyl)-1H-imidazole-4-carboxylate 27, potassium hydroxide and methyl tributylammonium hydrochloride were reacted at 65° C., cooled, and concentrated. The mixture was dissolved in ethanol and water to crystallize 28.

1. temperaturecooled
2. concentrationconcentrated
3. dissolutionThe mixture was dissolved in ethanol
4. customwater to crystallize 28