HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → HCID 178464937, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | 2-(2-(4-Bromo-2-fluorophenyl)-4-(1-isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-1H-imidazol-1-yl)ethanol | HCID 58204414 | — |
| Reactant | N'-isopropylacetohydrazonamide | HCID 74037752 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178464937 | HCID 178464937 | — |
Reaction Steps
Reaction of 30 with N′-isopropylacetohydrazonamide 6 and coupling reagent HBTU in DMF gives intermediate, 2-(4-bromo-2-fluorophenyl)-N-(1-(2-isopropylhydrazinyl)ethylidene)-1H-imidazole-4-carboxamide 31 which cyclizes upon heating to give V.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303043B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-4ff154cdadee4d9e87fcc0729b301b4a |
| Source note | uspto-grants-2016_04 |