4-Bromo-2-fluorobenzonitrile → Methyl 4-bromo-2-fluorobenzimidate

HRID 624645Notes

Reaction equation

HRID 624645 reaction equation

[Br:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([F:10])[CH:3]=1.[CH3:11][O-:12].[Na+]>CO>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([C:6](=[NH:7])[O:12][CH3:11])=[C:4]([F:10])[CH:3]=1

Participants

4

Reactant 2

HCID 7360294-Bromo-2-fluorobenzonitrile

HCID 10942334Sodium Methoxide

Product 1

HCID 71748447Methyl 4-bromo-2-fluorobenzimidate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Reaction of 4-bromo-2-fluorobenzonitrile 11 with sodium methoxide in methanol gives 35.

Sources & evidence

ORD record: ord-7acda12b9289433299a1fd0c8d520362
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09303043B2

Reaction notes

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