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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 624655Generated: October 30, 2026

Cesium carbonate → HCID 90031264, compound

https://huagongshe.com/reaction/624655

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCesium carbonateHCID 10796—
Reactant2-BromothiazoleHCID 76430—
ReactantMethyl indole-3-carboxylateHCID 589098—
SolventDimethylformamideHCID 6228—
SolventN-methyl-2-pyrrolidoneHCID 13387—
ProductHCID 90031264HCID 90031264—

Reaction Conditions

Temperature110 °C

Reaction Steps

To a solution of methyl 1H-indole-3-carboxylate (200 mg, 1.142 mmol) in NMP (Volume: 1142 μl) were added 2-bromothiazole (206 μl, 2.283 mmol) and cesium carbonate (1116 mg, 3.42 mmol) at RT. The mixture was heated at 110° C. for 2 h, then diluted with DMF, filtered and purified by HPLC to afford the title compound as a brown solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09303045B2
Source datasetuspto-grants-2016_04
ORD IDord-7dee03cd5d6a4cb8a509d3a3622a6b83
Source noteuspto-grants-2016_04