HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 624655Generated: October 30, 2026
Cesium carbonate → HCID 90031264, compound
https://huagongshe.com/reaction/624655
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Bromothiazole | HCID 76430 | — |
| Reactant | Methyl indole-3-carboxylate | HCID 589098 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 90031264 | HCID 90031264 | — |
Reaction Steps
To a solution of methyl 1H-indole-3-carboxylate (200 mg, 1.142 mmol) in NMP (Volume: 1142 μl) were added 2-bromothiazole (206 μl, 2.283 mmol) and cesium carbonate (1116 mg, 3.42 mmol) at RT. The mixture was heated at 110° C. for 2 h, then diluted with DMF, filtered and purified by HPLC to afford the title compound as a brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09303045B2 |
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| Source dataset | uspto-grants-2016_04 |
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| ORD ID | ord-7dee03cd5d6a4cb8a509d3a3622a6b83 |
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| Source note | uspto-grants-2016_04 |
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