HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 624666Generated: October 31, 2026
Potassium Phosphate, Tribasic → HCID 90031463, compound
https://huagongshe.com/reaction/624666
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | Methyl indole-3-carboxylate | HCID 589098 | — |
| Reactant | 5-Bromo-1-methyl-1H-imidazole | HCID 1515258 | — |
| Reactant | trans-N,N'-dimethyl-1,2-cyclohexanediamine | HCID 2733821 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 90031463 | HCID 90031463 | — |
Reaction Steps
A solution of methyl 1H-indole-3-carboxylate (300 mg, 1.712 mmol) and 5-bromo-1-methyl-1H-imidazole (303 mg, 1.884 mmol) in toluene (3425 μl) was treated with (1R,2R)—N1,N2-dimethylcyclohexane-1,2-diamine (82 μl, 0.514 mmol), potassium phosphate (763 mg, 3.60 mmol) and copper(I) iodide (98 mg, 0.514 mmol) and the resulting reaction mixture stirred at 110° C. overnight. HPLC purification afforded the title compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09303045B2 |
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| Source dataset | uspto-grants-2016_04 |
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| ORD ID | ord-b9e5fbb99bab498a941d43484e7537d3 |
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| Source note | uspto-grants-2016_04 |
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