HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 624668Generated: October 25, 2026
Cesium carbonate → methyl 1-(thiazol-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
https://huagongshe.com/reaction/624668
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Bromothiazole | HCID 76430 | — |
| Reactant | methyl 1H-pyrrolo[2,3-b]pyridine-3-carboxylate | HCID 21110084 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | methyl 1-(thiazol-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate | HCID 90030953 | — |
Reaction Steps
A mixture of methyl 1H-pyrrolo[2,3-b]pyridine-3-carboxylate (200 mg, 1.135 mmol), 2-bromothiazole (205 μl, 2.271 mmol) and cesium carbonate (1110 mg, 3.41 mmol) in NMP (1135 μl) was heated at 130° C. for 2 h. The mixture was then purified by HPLC to afford the title compound as a brownish-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09303045B2 |
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| Source dataset | uspto-grants-2016_04 |
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| ORD ID | ord-9cb94a1a285841d7a6191a7984af8102 |
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| Source note | uspto-grants-2016_04 |
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