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Trifluoroacetic acid → quinuclidin-4-yl 5-fluoro-1-(methylsulfonyl)-1H-indole-3-carboxylate 2,2,2-trifluoroacetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Trifluoroacetic anhydride | HCID 9845 | — |
| 反応物 | 1-Azabicyclo(2.2.2)octan-4-ol | HCID 141290 | — |
| 反応物 | 5-Fluoro-1-(methylsulfonyl)-1H-indole-3-carboxylic acid | HCID 90030984 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | quinuclidin-4-yl 5-fluoro-1-(methylsulfonyl)-1H-indole-3-carboxylate 2,2,2-trifluoroacetic acid | HCID 90031208 | — |
反応手順
In a vial containing 5-fluoro-1-(methylsulfonyl)-1H-indole-3-carboxylic acid (20 mg, 0.078 mmol; see Reference 10 for the synthesis) and trifluoroacetic anhydride (10.98 μl, 0.078 mmol) in toluene (259 μl) was added TFA (64.8 μl). After 30 min, quinuclidin-4-ol (8.24 mg, 0.065 mmol) was added and the mixture was stirred at RT overnight. Direct HPLC purification (after dilution with DMF and filtration) gave the title compound as a clear film. MS (ESI, pos. ion) m/z: 367.2 (M+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09303045B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-b885b1d9b92d4236ac90212911fe267c |
| 出典メモ | uspto-grants-2016_04 |