HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-4-(3-(3-cyclopropyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-8-yl)-8-((2,4-dimethoxybenzyl)amino)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide → HCID 76901982, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-4-(3-(3-cyclopropyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-8-yl)-8-((2,4-dimethoxybenzyl)amino)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide | HCID 90303966 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | HCID 76901982 | HCID 76901982 | — |
Reaction Steps
A solution of (S)-4-(3-(3-cyclopropyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-8-yl)-8-((2,4-dimethoxybenzyl)amino)imidazo[1,5-a]pyrazin-1-yl)-N-(4-(trifluoromethyl)pyridin-2-yl)benzamide (30 mg, 0.04 mmol) in TFA (1.5 mL) was stirred at 110° C. for 2 hrs. The reaction mixture was purified by Pre-HPLC to give the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09446130B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-8d589528971648698881d3f65c026d3b |
| Source note | uspto-grants-2016_09 |